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Scientific Validation of BIA

Historically, the applications of Bioelectrical Impedance Analysis (BIA) have been focused on human body composition. Although peer reviewed literature describes a wide variety of various disease or population specific applications, the migration of BIA technology from research to clinical applications has been slow. One possible cause may be the fact that the potential usefulness of BIA is so widespread and involves so many different medical specialties. Consequently, development of validated applications and the necessary FDA clearances will take time. It is interesting to note that “From 2000 to 2006, the number of papers cited in Medline and containing the keywords ‘bio-impedance’ or ‘impedance tomography’ increased by 56%.” (IOP Science) It is obvious that interest in BIA continues to grow.

2025 SEPT 20 | NATIONAL LIBRARY OF MEDICINE

Body composition in patients with obesity-related heart failure with preserved ejection fraction: A comparison study

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2025 SEPT 30 | THE EUROPEAN SOCIETY OF MEDICINE

Segmental electrical bioimpedance myography in normals and in patients with neuromuscular diseases: a case series

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2020 SEPT | NATIONAL LIBRARY OF MEDICINE

Segmental body composition evaluation by bioelectrical impedance analysis and dual-energy X-ray absorptiometry: Quantifying agreement between methods

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2007 AUG | JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Validation of Bioelectrical Impedance Against Dual-Energy X-Ray Absorptiometry in Adult, African American Females

M.W. Valliant, D.K. Tidwell

The assessment of body composition (BC), specifically fat mass and fat-free mass is an important component of establishing nutritional status. Bioelectrical impedance (BIA) is a commonly used, non-invasive, low cost method to measure BC. African American (AA) females have a high rate of obesity so knowledge of BC is important to professionals working with this population. The objective of this study was to compare BIA (hand to foot model) to dual-energy X-ray absorptiometry (DXA) as the reference. BC was assessed by BIA (BIA 101 RJL System) and DXA (Hologic Delphi-W) in 100 healthy, AA females 18 – 40 years old with various body mass indices (range 17 – 47 kg/m2; mean = 29.53 +/- 6.86 s.d.). Both measures were completed in the morning following an overnight fast, physical inactivity for the previous 24 hours and in the supine position. Pearson.s correlation coefficient 0.94 (p = .01) indicated a strong correlation between the two methods and no significant statistical difference between the means (p = .72). Bland and Altman analysis showed strong agreement between the two methods across the range of body fat percentages indicating that they are comparable methods for measuring body fat percentage at lower and higher percentages of body fat. In conclusion, BIA is a suitable method to assess BC in adult AA females when factors such as food and beverage intake and physical activity are controlled.

2006 | INTERNATIONAL JOURNAL OF BODY COMPOSITION RESEARCH

Validation of Bioelectrical Impedance Analysis (BIA) for Estimation of Body Composition in Black, White and Hispanic Adolescent Girls

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2006 MAR | OBESITY (SILVER SPRING)

Comparison of Body Composition Methods in Obese African-American Women

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2004 JUL | ANALES DE PEDIATRÍA

Body Composition Analysis Using Bioelectrical and Anthropometric Parameters

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2003 JUN | AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM

Body Composition Assessment in Extreme Obesity and After Massive Weight Loss Induced by Gastric Bypass Surgery

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2003 MAY | AMERICAN JOURNAL OF CLINICAL NUTRITION

Validation of Bioelectrical Impedance Analysis in Patients With Amyotrophic Lateral Sclerosis

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2000 AUG | NATIONAL LIBRARY OF MEDICINE

Estimation of skeletal muscle mass by bioelectrical impedance

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1993 MAY | PHYSICAL THERAPY

Cross-Validation of Bioelectrical Impedance Analysis of Body Composition in Children and Adolescents

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1988 JAN | AMERICAN JOURNAL OF CLINICAL NUTRITION

Lean Body Mass Estimation by Bioelectrical Impedance Analysis: A Four-Site Cross-Validation Study

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1986 APR | JOURNAL OF APPLIED PHYSIOLOGY

Validation of Tetrapolar Bioelectrical Impedance Method to Assess Human Body Composition

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Disclaimer: These papers and abstracts of papers have been published in peer-reviewed journals. They may draw conclusions and discuss applications of Bioelectrical Impedance Analysis which have not been reviewed by the FDA. Statements made within them are the sole responsibility of the authors. Unless otherwise indicated, no material support was provided to the authors or study investigators by RJL Systems.